De spontaneo viventium ortu
A 1618 Latin treatise by the Italian philosopher and physician Fortunio Liceti, printed in Vicenza, on whether living things arise spontaneously from non-living matter, written for scholars of natural philosophy and medicine. The pages are dense Latin text set in two columns with heavy marginal annotations and citations, and the index pictures show a few spare alphabetical subject entries with page references, so a designer might borrow the crowded layered text-and-margin structure for a dense typographic layout.
